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PCNA-related progressive neurodegenerative photosensitivity syndrome

ORPHA:438134DiseaseAutosomal recessiveInfancy, Neonatal

Ассоциированные гены (1)

PCNA
proliferating cell nuclear antigen
Disease-causing germline mutation(s) in
OMIM: 176740

Фенотипы (16)

Очень частый (80–99%)7
HP:0000365Hearing impairment
HP:0000613Photophobia
HP:0000992Cutaneous photosensitivity
HP:0001263Global developmental delay
HP:0002066Gait ataxia
HP:0002180Neurodegeneration
HP:0100585Telangiectasia of the skin
Частый (30–79%)4
HP:0001256Intellectual disability, mild
HP:0004322Short stature
HP:0007763Retinal telangiectasia
HP:0031087Absent pubertal growth spurt
Периодический (5–29%)5
HP:0000252Microcephaly
HP:0000776Congenital diaphragmatic hernia
HP:0001272Cerebellar atrophy
HP:0002664Neoplasm
HP:0010864Intellectual disability, severe

Эпидемиология (2)

Cases/families
Worldwide
Point prevalence
<1 / 1 000 000
Worldwide

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы