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X-linked lissencephaly with abnormal genitalia

ORPHA:452Malformation syndromeX-linked recessiveNeonatal

Ассоциированные гены (1)

ARX
aristaless related homeobox
Disease-causing germline mutation(s) (loss of function) in
OMIM: 300382

Фенотипы (21)

Очень частый (80–99%)9
HP:0000028Cryptorchidism
HP:0000062Ambiguous genitalia
HP:0000252Microcephaly
HP:0001249Intellectual disability
HP:0001250Seizure
HP:0001263Global developmental delay
HP:0001274Agenesis of corpus callosum
HP:0001302Pachygyria
HP:0008736Hypoplasia of penis
Частый (30–79%)5
HP:0000966Hypohidrosis
HP:0001252Hypotonia
HP:0001522Death in infancy
HP:0002024Malabsorption
HP:0002119Ventriculomegaly
Периодический (5–29%)7
HP:0000347Micrognathia
HP:0001257Spasticity
HP:0001629Ventricular septal defect
HP:0001643Patent ductus arteriosus
HP:0001738Exocrine pancreatic insufficiency
HP:0002251Aganglionic megacolon
HP:0011220Prominent forehead

Эпидемиология (2)

Cases/families
Worldwide
Point prevalence
Unknown
Worldwide

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы