Chronic myeloid leukemia
ORPHA:521DiseaseNot applicableAdolescent, Adult, Childhood, Infancy
Ассоциированные гены3
| Ген | Полное название | Тип связи | Тип гена | OMIM |
|---|---|---|---|---|
| BCR | BCR activator of RhoGEF and GTPase | Part of a fusion gene in | gene with protein product | 151410 |
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase | Part of a fusion gene in | gene with protein product | 189980 |
| RUNX1 | RUNX family transcription factor 1 | Biomarker tested in | gene with protein product | 151385 |
Фенотипы (HPO)11
Облигатный (100%)1
HP:0005547Myeloproliferative disorder
Частый (30–79%)10
HP:0001744Splenomegaly
HP:0001871Abnormality of blood and blood-forming tissues
HP:0001873Thrombocytopenia
HP:0001894Thrombocytosis
HP:0001911Abnormality of granulocytes
HP:0001912Abnormality of basophils
HP:0001945Fever
HP:0001974Leukocytosis
HP:0004396Poor appetite
HP:0012378Fatigue
Эпидемиология5
| Тип оценки | Класс распространённости | Среднее (на 100к) | Регион | Квалификация |
|---|---|---|---|---|
| Annual incidence | 1-9 / 100 000 | 1.25 | Europe | Value and class |
| Annual incidence | 1-9 / 100 000 | 1.25 | France | Value and class |
| Point prevalence | 1-9 / 100 000 | 6 | Europe | Value and class |
| Lifetime Prevalence | 1-9 / 100 000 | 5.63 | Europe | Value and class |
| Annual incidence | 1-9 / 100 000 | 1.7 | United States | Value and class |
Лекарства и терапия
Источник: Open Targets Platform (в реальном времени)
Клинические исследования
Источник: ClinicalTrials.gov (в реальном времени)