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Early-onset familial hypoaldosteronism

ORPHA:556030Clinical subtypeAutosomal recessiveAdolescent, Childhood, Infancy, Neonatal

Ассоциированные гены (1)

CYP11B2
cytochrome P450 family 11 subfamily B member 2
Disease-causing germline mutation(s) in
OMIM: 124080

Фенотипы (16)

Очень частый (80–99%)6
HP:0001508Failure to thrive
HP:0002153Hyperkalemia
HP:0002615Hypotension
HP:0002902Hyponatremia
HP:0008897Postnatal growth retardation
HP:0012606Renal sodium wasting
Частый (30–79%)9
HP:0000848Increased circulating renin level
HP:0001278Orthostatic hypotension
HP:0001290Generalized hypotonia
HP:0001944Dehydration
HP:0002013Vomiting
HP:0004319Decreased circulating aldosterone level
HP:0011968Feeding difficulties
HP:0012112Abnormality of circulating corticosterone level
HP:0025436Elevated serum 11-deoxycortisol
Исключён (0%)1
HP:0000811Abnormal external genitalia

Эпидемиология (1)

Point prevalence
Unknown
Worldwide

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы