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Sorsby fundus dystrophy

ORPHA:59181DiseaseAutosomal dominantAdult

Ассоциированные гены (1)

TIMP3
TIMP metallopeptidase inhibitor 3
Disease-causing germline mutation(s) in
OMIM: 188826

Фенотипы (17)

Очень частый (80–99%)4
HP:0000572Visual loss
HP:0007754Macular dystrophy
HP:0030500Yellow/white lesions of the macula
HP:0031528Subretinal deposits
Частый (30–79%)7
HP:0000610Abnormal choroid morphology
HP:0000662Nyctalopia
HP:0001129Large central visual field defect
HP:0011506Choroidal neovascularization
HP:0030491Choriocapillaris atrophy
HP:0030602Abnormal fundus autofluorescence imaging
HP:0030625Hyporeflective spaces on macular OCT
Периодический (5–29%)6
HP:0000533Chorioretinal atrophy
HP:0000580Pigmentary retinopathy
HP:0000618Blindness
HP:0001105Retinal atrophy
HP:0001141Severely reduced visual acuity
HP:0007722Retinal pigment epithelial atrophy

Эпидемиология (1)

Point prevalence
Unknown
Worldwide

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы