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Hereditary sensory and autonomic neuropathy type 5

ORPHA:64752DiseaseAutosomal recessiveInfancy, Neonatal

Ассоциированные гены (2)

NTRK1
neurotrophic receptor tyrosine kinase 1
Candidate gene tested in
OMIM: 191315
NGF
nerve growth factor
Disease-causing germline mutation(s) in
OMIM: 162030

Фенотипы (11)

Частый (30–79%)11
HP:0000164Abnormality of the dentition
HP:0000168Abnormality of the gingiva
HP:0000272Malar flattening
HP:0000490Deeply set eye
HP:0000970Anhidrosis
HP:0001058Poor wound healing
HP:0001256Intellectual disability, mild
HP:0002661Painless fractures due to injury
HP:0007021Pain insensitivity
HP:0007249Decreased number of small peripheral myelinated nerve fibers
HP:0010829Impaired temperature sensition

Эпидемиология (2)

Point prevalence
<1 / 1 000 000
Europe
Point prevalence
<1 / 1 000 000
Japan

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы