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Lhermitte-Duclos disease

ORPHA:65285Clinical subtypeAutosomal dominant, Not applicableAdult

Ассоциированные гены (1)

PTEN
phosphatase and tensin homolog
Disease-causing germline mutation(s) (loss of function) in
OMIM: 601728

Фенотипы (18)

Очень частый (80–99%)13
HP:0000158Macroglossia
HP:0000238Hydrocephalus
HP:0000256Macrocephaly
HP:0001161Hand polydactyly
HP:0001250Seizure
HP:0001251Ataxia
HP:0002017Nausea and vomiting
HP:0002126Polymicrogyria
HP:0002315Headache
HP:0002516Increased intracranial pressure
HP:0006824Cranial nerve paralysis
HP:0012081Enlarged cerebellum
HP:0200034Papule
Частый (30–79%)5
HP:0010619Fibroadenoma of the breast
HP:0012844Trichilemmoma
HP:0100031Neoplasm of the thyroid gland
HP:0100615Ovarian neoplasm
HP:0200016Acrokeratosis

Эпидемиология (2)

Cases/families
Worldwide
Point prevalence
<1 / 1 000 000
Worldwide

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы