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Goldberg-Shprintzen megacolon syndrome

ORPHA:66629Malformation syndromeAutosomal recessiveInfancy, Neonatal

Ассоциированные гены (1)

KIFBP
kinesin family binding protein
Disease-causing germline mutation(s) (loss of function) in
OMIM: 609367

Фенотипы (23)

Очень частый (80–99%)6
HP:0000175Cleft palate
HP:0000252Microcephaly
HP:0001249Intellectual disability
HP:0001328Specific learning disability
HP:0002251Aganglionic megacolon
HP:0004322Short stature
Частый (30–79%)3
HP:0000508Ptosis
HP:0000612Iris coloboma
HP:0001252Hypotonia
Периодический (5–29%)14
HP:0000047Hypospadias
HP:0000048Bifid scrotum
HP:0000307Pointed chin
HP:0000316Hypertelorism
HP:0000340Sloping forehead
HP:0000400Macrotia
HP:0000431Wide nasal bridge
HP:0001250Seizure
HP:0001302Pachygyria
HP:0002079Hypoplasia of the corpus callosum
HP:0002119Ventriculomegaly
HP:0002209Sparse scalp hair
HP:0006101Finger syndactyly
HP:0045075Sparse eyebrow

Эпидемиология (2)

Cases/families
Worldwide
Point prevalence
<1 / 1 000 000
Worldwide

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы