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Late-onset retinal degeneration

ORPHA:67042DiseaseAutosomal dominantAdult, Elderly

Ассоциированные гены (1)

C1QTNF5
C1q and TNF related 5
Disease-causing germline mutation(s) in
OMIM: 608752

Фенотипы (22)

Очень частый (80–99%)1
HP:0030534Abnormal best corrected visual acuity test
Частый (30–79%)9
HP:0000533Chorioretinal atrophy
HP:0000572Visual loss
HP:0000608Macular degeneration
HP:0000662Nyctalopia
HP:0001141Severely reduced visual acuity
HP:0007791Patchy atrophy of the retinal pigment epithelium
HP:0011506Choroidal neovascularization
HP:0011510Drusen
HP:0031530Multifocal subretinal deposits
Периодический (5–29%)10
HP:0000552Tritanomaly
HP:0000613Photophobia
HP:0000642Red-green dyschromatopsia
HP:0001089Iris atrophy
HP:0001099Fundus atrophy
HP:0004328Abnormal anterior eye segment morphology
HP:0007401Macular atrophy
HP:0012628Abnormal suspensory ligament of lens morphology
HP:0012805Iris transillumination defect
HP:0500087Peripapillary atrophy
Очень редкий (1–4%)2
HP:0007906Ocular hypertension
HP:0100014Epiretinal membrane

Эпидемиология (1)

Point prevalence
Unknown
Worldwide

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы