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Hemolytic anemia due to glucophosphate isomerase deficiency

ORPHA:712DiseaseAutosomal recessiveInfancy, Neonatal

Ассоциированные гены (1)

GPI
glucose-6-phosphate isomerase
Disease-causing germline mutation(s) in
OMIM: 172400

Фенотипы (13)

Частый (30–79%)8
HP:0000952Jaundice
HP:0001744Splenomegaly
HP:0001923Reticulocytosis
HP:0001930Nonspherocytic hemolytic anemia
HP:0002240Hepatomegaly
HP:0003568Decreased glucosephosphate isomerase level
HP:0008282Unconjugated hyperbilirubinemia
HP:0025435Increased circulating lactate dehydrogenase concentration
Периодический (5–29%)5
HP:0001082Cholecystitis
HP:0001249Intellectual disability
HP:0001789Hydrops fetalis
HP:0004447Poikilocytosis
HP:0011981Pigment gallstones

Эпидемиология (2)

Cases/families
Worldwide
Point prevalence
<1 / 1 000 000
Worldwide

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы