← Назад

46,XY difference of sex development due to 17-beta-hydroxysteroid dehydrogenase 3 deficiency

ORPHA:752DiseaseAutosomal recessiveAdolescent, Neonatal

Ассоциированные гены (1)

HSD17B3
hydroxysteroid 17-beta dehydrogenase 3
Disease-causing germline mutation(s) (loss of function) in
OMIM: 605573

Фенотипы (12)

Очень частый (80–99%)6
HP:0000028Cryptorchidism
HP:0000037Male pseudohermaphroditism
HP:0000047Hypospadias
HP:0000062Ambiguous genitalia
HP:0000789Infertility
HP:0008665Clitoral hypertrophy
Частый (30–79%)3
HP:0000023Inguinal hernia
HP:0025380Increased circulating androstenedione concentration
HP:0100779Urogenital sinus anomaly
Периодический (5–29%)3
HP:0000048Bifid scrotum
HP:0000771Gynecomastia
HP:0008736Hypoplasia of penis

Эпидемиология (2)

Prevalence at birth
1-9 / 1 000 000
Netherlands
Point prevalence
1-9 / 1 000 000
Netherlands

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы