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Generalized glucocorticoid resistance syndrome

ORPHA:786DiseaseAutosomal dominant, Autosomal recessive, Not applicableAll ages

Ассоциированные гены (1)

NR3C1
nuclear receptor subfamily 3 group C member 1
Disease-causing germline mutation(s) in
OMIM: 138040

Фенотипы (21)

Очень частый (80–99%)5
HP:0001007Hirsutism
HP:0003154Increased circulating ACTH level
HP:0004319Decreased circulating aldosterone level
HP:0012030Increased urinary cortisol level
HP:0012378Fatigue
Частый (30–79%)7
HP:0000822Hypertension
HP:0000876Oligomenorrhea
HP:0001061Acne
HP:0002900Hypokalemia
HP:0008221Adrenal hyperplasia
HP:0030087Abnormal testosterone level
HP:0200114Metabolic alkalosis
Периодический (5–29%)8
HP:0000062Ambiguous genitalia
HP:0000789Infertility
HP:0000798Oligozoospermia
HP:0000826Precocious puberty
HP:0001943Hypoglycemia
HP:0002292Frontal balding
HP:0003118Increased circulating cortisol level
HP:0010458Female pseudohermaphroditism
Очень редкий (1–4%)1
HP:0001297Stroke

Эпидемиология (1)

Point prevalence
Unknown
Worldwide

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы