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Eiken syndrome

ORPHA:79106Malformation syndromeAutosomal recessiveInfancy, Neonatal

Ассоциированные гены (1)

PTH1R
parathyroid hormone 1 receptor
Disease-causing germline mutation(s) in
OMIM: 168468

Фенотипы (23)

Очень частый (80–99%)3
HP:0002656Epiphyseal dysplasia
HP:0002829Arthralgia
HP:0006376Limited elbow flexion
Частый (30–79%)20
HP:0001169Broad palm
HP:0001211Abnormal fingertip morphology
HP:0001769Broad foot
HP:0001773Short foot
HP:0001831Short toe
HP:0002663Delayed epiphyseal ossification
HP:0002753Thin bony cortex
HP:0002967Cubitus valgus
HP:0003025Metaphyseal irregularity
HP:0003038Fibular hypoplasia
HP:0003170Abnormality of the acetabulum
HP:0003275Narrow pelvis bone
HP:0004279Short palm
HP:0004322Short stature
HP:0008800Limited hip movement
HP:0008808High iliac wings
HP:0009803Short phalanx of finger
HP:0010305Absence of the sacrum
HP:0011849Abnormal bone ossification
HP:0100671Abnormal trabecular bone morphology

Эпидемиология (2)

Cases/families
Worldwide
Point prevalence
<1 / 1 000 000
Worldwide

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы