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3-phosphoserine phosphatase deficiency, infantile/juvenile form

ORPHA:79350Etiological subtypeAutosomal recessiveInfancy

Ассоциированные гены (1)

PSPH
phosphoserine phosphatase
Disease-causing germline mutation(s) in
OMIM: 172480

Фенотипы (18)

Частый (30–79%)5
HP:0001263Global developmental delay
HP:0002342Intellectual disability, moderate
HP:0008897Postnatal growth retardation
HP:0011968Feeding difficulties
HP:0012279Hyposerinemia
Периодический (5–29%)13
HP:0000047Hypospadias
HP:0000154Wide mouth
HP:0000252Microcephaly
HP:0000293Full cheeks
HP:0000337Broad forehead
HP:0000341Narrow forehead
HP:0000347Micrognathia
HP:0001276Hypertonia
HP:0001999Abnormal facial shape
HP:0002020Gastroesophageal reflux
HP:0002069Bilateral tonic-clonic seizure
HP:0100540Palpebral edema
HP:0100633Esophagitis

Эпидемиология (2)

Cases/families
Worldwide
Point prevalence
<1 / 1 000 000
Worldwide

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы