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IMAGe syndrome

ORPHA:85173Malformation syndromeAutosomal dominant, Autosomal recessiveInfancy, Neonatal

Ассоциированные гены (2)

CDKN1C
cyclin dependent kinase inhibitor 1C
Disease-causing germline mutation(s) in
OMIM: 600856
POLE
DNA polymerase epsilon, catalytic subunit
Disease-causing germline mutation(s) (loss of function) in
OMIM: 174762

Фенотипы (13)

Очень частый (80–99%)13
HP:0000028Cryptorchidism
HP:0000047Hypospadias
HP:0000078Abnormality of the genital system
HP:0000126Hydronephrosis
HP:0000135Hypogonadism
HP:0000369Low-set ears
HP:0000835Adrenal hypoplasia
HP:0001252Hypotonia
HP:0001511Intrauterine growth retardation
HP:0002007Frontal bossing
HP:0002983Micromelia
HP:0005280Depressed nasal bridge
HP:0100255Metaphyseal dysplasia

Эпидемиология (2)

Cases/families
Worldwide
Point prevalence
<1 / 1 000 000
Worldwide

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы