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Keutel syndrome

ORPHA:85202Malformation syndromeAutosomal recessiveChildhood

Ассоциированные гены (1)

MGP
matrix Gla protein
Disease-causing germline mutation(s) (loss of function) in
OMIM: 154870

Фенотипы (24)

Очень частый (80–99%)8
HP:0000276Long face
HP:0000445Wide nose
HP:0004415Pulmonary artery stenosis
HP:0005280Depressed nasal bridge
HP:0009882Short distal phalanx of finger
HP:0011800Midface retrusion
HP:0100593Calcification of cartilage
HP:0100682Tracheal atresia
Частый (30–79%)10
HP:0000340Sloping forehead
HP:0000365Hearing impairment
HP:0000403Recurrent otitis media
HP:0000430Underdeveloped nasal alae
HP:0001256Intellectual disability, mild
HP:0001263Global developmental delay
HP:0001629Ventricular septal defect
HP:0002092Pulmonary arterial hypertension
HP:0002205Recurrent respiratory infections
HP:0011108Recurrent sinusitis
Периодический (5–29%)6
HP:0000648Optic atrophy
HP:0001027Soft, doughy skin
HP:0001250Seizure
HP:0001596Alopecia
HP:0004322Short stature
HP:0004334Dermal atrophy

Эпидемиология (2)

Cases/families
Worldwide
Point prevalence
<1 / 1 000 000
Worldwide

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы