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X-linked intellectual disability, Cantagrel type

ORPHA:85277Malformation syndromeX-linked recessiveInfancy, Neonatal

Ассоциированные гены (1)

NEXMIF
neurite extension and migration factor
Disease-causing germline mutation(s) (loss of function) in
OMIM: 300524

Фенотипы (18)

Очень частый (80–99%)11
HP:0000322Short philtrum
HP:0000729Autistic behavior
HP:0000733Abnormal repetitive mannerisms
HP:0001249Intellectual disability
HP:0001319Neonatal hypotonia
HP:0001344Absent speech
HP:0002120Cerebral cortical atrophy
HP:0002273Tetraparesis
HP:0003196Short nose
HP:0010804Tented upper lip vermilion
HP:0011344Severe global developmental delay
Частый (30–79%)7
HP:0000049Shawl scrotum
HP:0000565Esotropia
HP:0001250Seizure
HP:0002020Gastroesophageal reflux
HP:0002079Hypoplasia of the corpus callosum
HP:0002119Ventriculomegaly
HP:0003011Abnormality of the musculature

Эпидемиология (2)

Cases/families
Worldwide
Point prevalence
<1 / 1 000 000
Worldwide

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы