Acute myeloid leukaemia with myelodysplasia-related features
ORPHA:86845DiseaseNot applicableAdult
Ассоциированные гены5
| Ген | Полное название | Тип связи | Тип гена | OMIM |
|---|---|---|---|---|
| TET2 | tet methylcytosine dioxygenase 2 | Disease-causing somatic mutation(s) in | gene with protein product | 612839 |
| IDH1 | isocitrate dehydrogenase (NADP(+)) 1 | Disease-causing somatic mutation(s) in | gene with protein product | 147700 |
| IDH2 | isocitrate dehydrogenase (NADP(+)) 2 | Disease-causing somatic mutation(s) in | gene with protein product | 147650 |
| ASXL1 | ASXL transcriptional regulator 1 | Disease-causing somatic mutation(s) in | gene with protein product | 612990 |
| DNMT3A | DNA methyltransferase 3 alpha | Disease-causing somatic mutation(s) in | gene with protein product | 602769 |
Эпидемиология1
| Тип оценки | Класс распространённости | Среднее (на 100к) | Регион | Квалификация |
|---|---|---|---|---|
| Annual incidence | <1 / 1 000 000 | — | Europe | Class only |
Лекарства и терапия
Источник: Open Targets Platform (в реальном времени)
Клинические исследования
Источник: ClinicalTrials.gov (в реальном времени)