TSH-secreting pituitary adenoma
ORPHA:91347DiseaseAdolescent, Adult, Childhood, Elderly
Ассоциированные гены1
Фенотипы (HPO)66
Очень частый (80–99%)5
HP:0000836Hyperthyroidism
HP:0000853Goiter
HP:0002925Elevated circulating thyroid-stimulating hormone concentration
HP:0012503Abnormality of the pituitary gland
HP:0012505Enlarged pituitary gland
Частый (30–79%)33
HP:0000026Male hypogonadism
HP:0000044Hypogonadotropic hypogonadism
HP:0000134Female hypogonadism
HP:0000135Hypogonadism
HP:0000140Abnormality of the menstrual cycle
HP:0000529Progressive visual loss
HP:0000771Gynecomastia
HP:0000802Impotence
HP:0000858Irregular menstruation
HP:0000868Decreased fertility in females
HP:0000938Osteopenia
HP:0000939Osteoporosis
HP:0000975Hyperhidrosis
HP:0000980Pallor
HP:0001337Tremor
HP:0001824Weight loss
HP:0001962Palpitations
HP:0002013Vomiting
HP:0002017Nausea and vomiting
HP:0002315Headache
HP:0002615Hypotension
HP:0002920Decreased circulating ACTH level
HP:0003388Easy fatigability
HP:0008240Secondary growth hormone deficiency
HP:0011362Abnormal hair quantity
HP:0011734Central adrenal insufficiency
HP:0011735Adrenocorticotropin deficient adrenal insufficiency
HP:0011748Adrenocorticotropic hormone deficiency
HP:0011782Thyroid crisis
HP:0012041Decreased fertility in males
HP:0012378Fatigue
HP:0030018Decreased female libido
HP:0100639Erectile dysfunction
Периодический (5–29%)28
HP:0000508Ptosis
HP:0000618Blindness
HP:0000651Diplopia
HP:0000789Infertility
HP:0000822Hypertension
HP:0000823Delayed puberty
HP:0000837Increased circulating gonadotropin level
HP:0000845Elevated circulating growth hormone concentration
HP:0000870Increased circulating prolactin concentration
HP:0001117Sudden loss of visual acuity
HP:0001250Seizure
HP:0001635Congestive heart failure
HP:0001698Pericardial effusion
HP:0002321Vertigo
HP:0002900Hypokalemia
HP:0004308Ventricular arrhythmia
HP:0005115Supraventricular arrhythmia
HP:0006824Cranial nerve paralysis
HP:0006897Abducens palsy
HP:0007011Fourth cranial nerve palsy
HP:0007942Internal ophthalmoplegia
HP:0008153Periodic hypokalemic paresis
HP:0008247Euthyroid hyperthyroxinemia
HP:0012246Oculomotor nerve palsy
HP:0012377Hemianopia
HP:0030517Heteronymous hemianopia
HP:0030521Bitemporal hemianopia
HP:0030588Abnormal visual field test
Эпидемиология1
| Тип оценки | Класс распространённости | Среднее (на 100к) | Регион | Квалификация |
|---|---|---|---|---|
| Point prevalence | 1-9 / 1 000 000 | 0.28 | Sweden | Value and class |
Лекарства и терапия
Источник: Open Targets Platform (в реальном времени)
Клинические исследования
Источник: ClinicalTrials.gov (в реальном времени)