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HNF1B-related autosomal dominant tubulointerstitial kidney disease

ORPHA:93111Clinical subtypeAutosomal dominantAdolescent, Adult, Antenatal, Childhood, Infancy, Neonatal

Ассоциированные гены (1)

HNF1B
HNF1 homeobox B
Disease-causing germline mutation(s) in
OMIM: 189907

Фенотипы (29)

Очень частый (80–99%)2
HP:0000003Multicystic kidney dysplasia
HP:0000083Renal insufficiency
Частый (30–79%)1
HP:0000819Diabetes mellitus
Периодический (5–29%)26
HP:0000047Hypospadias
HP:0000085Horseshoe kidney
HP:0000104Renal agenesis
HP:0000303Mandibular prognathia
HP:0000365Hearing impairment
HP:0000813Bicornuate uterus
HP:0000821Hypothyroidism
HP:0000952Jaundice
HP:0001249Intellectual disability
HP:0001263Global developmental delay
HP:0001369Arthritis
HP:0001397Hepatic steatosis
HP:0001919Acute kidney injury
HP:0001959Polydipsia
HP:0001994Renal Fanconi syndrome
HP:0002021Pyloric stenosis
HP:0002149Hyperuricemia
HP:0002910Elevated circulating hepatic transaminase concentration
HP:0005584Renal cell carcinoma
HP:0009715Papillary cystadenoma of the epididymis
HP:0012092Abnormality of exocrine pancreas physiology
HP:0012093Abnormality of endocrine pancreas physiology
HP:0012873Absent vas deferens
HP:0100800Aplasia/Hypoplasia of the pancreas
HP:0100820Glomerulopathy
HP:0001382Joint hypermobility

Эпидемиология (1)

Point prevalence
Unknown
Europe

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы