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Brachydactyly type C

ORPHA:93384Malformation syndromeAutosomal dominant, Autosomal recessiveInfancy, Neonatal

Ассоциированные гены (2)

BMPR1B
bone morphogenetic protein receptor type 1B
Candidate gene tested in
OMIM: 603248
GDF5
growth differentiation factor 5
Disease-causing germline mutation(s) (loss of function) in
OMIM: 601146

Фенотипы (14)

Очень частый (80–99%)5
HP:0005819Short middle phalanx of finger
HP:0009373Type C brachydactyly
HP:0009465Ulnar deviation of finger
HP:0009495Pseudoepiphyses of the 2nd finger
HP:0010026Aplasia/Hypoplasia of the 1st metacarpal
Частый (30–79%)5
HP:0001231Abnormal fingernail morphology
HP:0009606Complete duplication of distal phalanx of the thumb
HP:0009684Stippling of the epiphysis of the distal phalanx of the thumb
HP:0010579Cone-shaped epiphysis
HP:0010743Short metatarsal
Периодический (5–29%)4
HP:0004209Clinodactyly of the 5th finger
HP:0004322Short stature
HP:0009773Symphalangism affecting the phalanges of the hand
HP:0010508Metatarsus valgus

Эпидемиология (1)

Point prevalence
Unknown
Worldwide

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы