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Spinocerebellar ataxia type 8

ORPHA:98760DiseaseAutosomal dominantAdult

Ассоциированные гены (2)

ATXN8
ataxin 8
Disease-causing germline mutation(s) in
OMIM: 613289
ATXN8OS
ATXN8 opposite strand lncRNA
Disease-causing germline mutation(s) in
OMIM: 603680

Фенотипы (23)

Частый (30–79%)15
HP:0000639Nystagmus
HP:0000802Impotence
HP:0001251Ataxia
HP:0001257Spasticity
HP:0001272Cerebellar atrophy
HP:0001332Dystonia
HP:0001347Hyperreflexia
HP:0002063Rigidity
HP:0002066Gait ataxia
HP:0002067Bradykinesia
HP:0002070Limb ataxia
HP:0002172Postural instability
HP:0002317Unsteady gait
HP:0002464Spastic dysarthria
HP:0006855Cerebellar vermis atrophy
Периодический (5–29%)8
HP:0000020Urinary incontinence
HP:0000273Facial grimacing
HP:0000716Depression
HP:0002015Dysphagia
HP:0002495Impaired vibratory sensation
HP:0002835Aspiration
HP:0007772Impaired smooth pursuit
HP:0012110Hypoplasia of the pons

Эпидемиология (1)

Point prevalence
Unknown
Worldwide

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы