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Hyperparathyroidism-jaw tumor syndrome

ORPHA:99880DiseaseAutosomal dominantAdolescent, Adult

Ассоциированные гены (1)

CDC73
cell division cycle 73
Disease-causing germline mutation(s) (gain of function) in
OMIM: 607393

Фенотипы (34)

Облигатный (100%)3
HP:0002897Parathyroid adenoma
HP:0003072Hypercalcemia
HP:0008200Primary hyperparathyroidism
Очень частый (80–99%)4
HP:0002148Hypophosphatemia
HP:0002150Hypercalciuria
HP:0003165Elevated circulating parathyroid hormone level
HP:0011766Abnormality of the parathyroid morphology
Частый (30–79%)9
HP:0000121Nephrocalcinosis
HP:0000131Uterine leiomyoma
HP:0000787Nephrolithiasis
HP:0000939Osteoporosis
HP:0001959Polydipsia
HP:0002015Dysphagia
HP:0010614Fibroma
HP:0012232Shortened QT interval
HP:0012378Fatigue
Периодический (5–29%)13
HP:0000083Renal insufficiency
HP:0000107Renal cyst
HP:0000934Chondrocalcinosis
HP:0001324Muscle weakness
HP:0001733Pancreatitis
HP:0002017Nausea and vomiting
HP:0002019Constipation
HP:0002315Headache
HP:0002574Episodic abdominal pain
HP:0002653Bone pain
HP:0004398Peptic ulcer
HP:0008696Renal hamartoma
HP:0200025Mandibular pain
Очень редкий (1–4%)5
HP:0002667Nephroblastoma
HP:0002890Thyroid carcinoma
HP:0006725Pancreatic adenocarcinoma
HP:0010788Testicular neoplasm
HP:0012032Lipoma

Эпидемиология (2)

Cases/families
Worldwide
Point prevalence
<1 / 1 000 000
Worldwide

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы