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X-linked Charcot-Marie-Tooth disease type 4

ORPHA:101078DiseaseX-linked recessiveChildhood, Infancy, Neonatal

Ассоциированные гены (1)

AIFM1
apoptosis inducing factor mitochondria associated 1
Disease-causing germline mutation(s) in
OMIM: 300169

Фенотипы (16)

Очень частый (80–99%)7
HP:0000762Decreased nerve conduction velocity
HP:0000763Sensory neuropathy
HP:0001284Areflexia
HP:0001761Pes cavus
HP:0002460Distal muscle weakness
HP:0003202Skeletal muscle atrophy
HP:0007141Sensorimotor neuropathy
Частый (30–79%)5
HP:0000365Hearing impairment
HP:0001249Intellectual disability
HP:0002650Scoliosis
HP:0002808Kyphosis
HP:0007328Impaired pain sensation
Периодический (5–29%)4
HP:0001251Ataxia
HP:0001288Gait disturbance
HP:0001337Tremor
HP:0002360Sleep abnormality

Эпидемиология (2)

Cases/families
Worldwide
Point prevalence
<1 / 1 000 000
Worldwide

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы