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Caffey disease

ORPHA:1310Malformation syndromeAutosomal dominant, UnknownAntenatal, Childhood, Infancy, Neonatal

Ассоциированные гены (1)

COL1A1
collagen type I alpha 1 chain
Disease-causing germline mutation(s) in
OMIM: 120150

Фенотипы (14)

Очень частый (80–99%)2
HP:0005731Cortical irregularity
HP:0100658Cellulitis
Частый (30–79%)4
HP:0000708Atypical behavior
HP:0001945Fever
HP:0006465Periosteal thickening of long tubular bones
HP:0100963Hyperesthesia
Периодический (5–29%)8
HP:0000324Facial asymmetry
HP:0000520Proptosis
HP:0002093Respiratory insufficiency
HP:0002650Scoliosis
HP:0004490Calvarial hyperostosis
HP:0005791Cortical thickening of long bone diaphyses
HP:0008872Feeding difficulties in infancy
HP:0010702Increased circulating antibody level

Эпидемиология (2)

Point prevalence
Unknown
Worldwide
Cases/families
Worldwide

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы