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Arthrochalasia Ehlers-Danlos syndrome

ORPHA:1899DiseaseAutosomal dominantInfancy, Neonatal

Ассоциированные гены (2)

COL1A2
collagen type I alpha 2 chain
Disease-causing germline mutation(s) in
OMIM: 120160
COL1A1
collagen type I alpha 1 chain
Disease-causing germline mutation(s) in
OMIM: 120150

Фенотипы (26)

Очень частый (80–99%)18
HP:0000963Thin skin
HP:0000974Hyperextensible skin
HP:0001001Abnormality of subcutaneous fat tissue
HP:0001252Hypotonia
HP:0001373Joint dislocation
HP:0001385Hip dysplasia
HP:0001387Joint stiffness
HP:0002300Mutism
HP:0002381Aphasia
HP:0002673Coxa valga
HP:0002812Coxa vara
HP:0002827Hip dislocation
HP:0003510Severe short stature
HP:0005743Avascular necrosis of the capital femoral epiphysis
HP:0010529Echolalia
HP:0010547Muscle flaccidity
HP:0100699Scarring
HP:0001382Joint hypermobility
Частый (30–79%)6
HP:0000278Retrognathia
HP:0000286Epicanthus
HP:0000316Hypertelorism
HP:0000347Micrognathia
HP:0002650Scoliosis
HP:0005280Depressed nasal bridge
Периодический (5–29%)2
HP:0000023Inguinal hernia
HP:0100541Femoral hernia

Эпидемиология (1)

Point prevalence
Unknown
Worldwide

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы