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Epidermolytic palmoplantar keratoderma

ORPHA:2199DiseaseAutosomal dominantInfancy, Neonatal

Ассоциированные гены (3)

KRT1
keratin 1
Disease-causing germline mutation(s) (gain of function) in
OMIM: 139350
KRT9
keratin 9
Disease-causing germline mutation(s) in
OMIM: 607606
KRT16
keratin 16
Candidate gene tested in
OMIM: 148067

Фенотипы (15)

Очень частый (80–99%)2
HP:0000962Hyperkeratosis
HP:0000972Palmoplantar hyperkeratosis
Частый (30–79%)7
HP:0001217Clubbing
HP:0001220Interphalangeal joint contracture of finger
HP:0001231Abnormal fingernail morphology
HP:0007447Diffuse palmoplantar kyperkeratosis
HP:0010765Palmar hyperkeratosis
HP:0025092Epidermal acanthosis
HP:0032541Knuckle pad
Периодический (5–29%)6
HP:0000975Hyperhidrosis
HP:0008066Abnormal blistering of the skin
HP:0010829Impaired temperature sensition
HP:0010830Impaired tactile sensation
HP:0012385Camptodactyly
HP:0025114Hypergranulosis

Эпидемиология (1)

Point prevalence
1-9 / 100 000
Ireland

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы