Hereditary breast cancer
ORPHA:227535DiseaseAutosomal dominant, Multigenic/multifactorialAdult, Elderly
Ассоциированные гены10
| Ген | Полное название | Тип связи | Тип гена | OMIM |
|---|---|---|---|---|
| NQO2 | N-ribosyldihydronicotinamide:quinone dehydrogenase 2 | Major susceptibility factor in | gene with protein product | 160998 |
| ATM | ATM serine/threonine kinase | Major susceptibility factor in | gene with protein product | 607585 |
| CDH1 | cadherin 1 | Candidate gene tested in | gene with protein product | 192090 |
| BRCA1 | BRCA1 DNA repair associated | Major susceptibility factor in | gene with protein product | 113705 |
| BRCA2 | BRCA2 DNA repair associated | Major susceptibility factor in | gene with protein product | 600185 |
| PALB2 | partner and localizer of BRCA2 | Major susceptibility factor in | gene with protein product | 610355 |
| XRCC2 | X-ray repair cross complementing 2 | Major susceptibility factor in | gene with protein product | 600375 |
| KLLN | killin, p53 regulated DNA replication inhibitor | Major susceptibility factor in | gene with protein product | 612105 |
| RAD54L | RAD54 like | Candidate gene tested in | gene with protein product | 603615 |
| SLC67A1 | solute carrier family 67 member 1 | Candidate gene tested in | gene with protein product | 602631 |
Лекарства и терапия
Источник: Open Targets Platform (в реальном времени)
Клинические исследования
Источник: ClinicalTrials.gov (в реальном времени)