← Назад

Frontonasal dysplasia-alopecia-genital anomalies syndrome

ORPHA:228390Malformation syndromeAutosomal recessiveAntenatal, Infancy, Neonatal

Ассоциированные гены (1)

ALX4
ALX homeobox 4
Disease-causing germline mutation(s) in
OMIM: 605420

Фенотипы (30)

Очень частый (80–99%)19
HP:0000028Cryptorchidism
HP:0000135Hypogonadism
HP:0000248Brachycephaly
HP:0000289Broad philtrum
HP:0000316Hypertelorism
HP:0000430Underdeveloped nasal alae
HP:0000463Anteverted nares
HP:0000486Strabismus
HP:0000506Telecanthus
HP:0000582Upslanted palpebral fissure
HP:0000639Nystagmus
HP:0001256Intellectual disability, mild
HP:0001362Skull defect
HP:0001596Alopecia
HP:0002084Encephalocele
HP:0002342Intellectual disability, moderate
HP:0004440Coronal craniosynostosis
HP:0005280Depressed nasal bridge
HP:0011803Bifid nose
Частый (30–79%)11
HP:0000046Small scrotum
HP:0000164Abnormality of the dentition
HP:0000369Low-set ears
HP:0000568Microphthalmia
HP:0000698Conical tooth
HP:0001274Agenesis of corpus callosum
HP:0001511Intrauterine growth retardation
HP:0001562Oligohydramnios
HP:0002007Frontal bossing
HP:0002213Fine hair
HP:0002335Agenesis of cerebellar vermis

Эпидемиология (2)

Cases/families
Worldwide
Point prevalence
<1 / 1 000 000
Worldwide

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы