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Symptomatic form of Coffin-Lowry syndrome in female carriers

ORPHA:276630Malformation syndromeAutosomal dominant, Not applicableAntenatal, Infancy, Neonatal

Ассоциированные гены (1)

RPS6KA3
ribosomal protein S6 kinase A3
Disease-causing germline mutation(s) in
OMIM: 300075

Фенотипы (21)

Очень частый (80–99%)2
HP:0001176Large hands
HP:0001182Tapered finger
Периодический (5–29%)19
HP:0000232Everted lower lip vermilion
HP:0000316Hypertelorism
HP:0000445Wide nose
HP:0000494Downslanted palpebral fissures
HP:0000674Anodontia
HP:0000677Oligodontia
HP:0000709Psychosis
HP:0000716Depression
HP:0000767Pectus excavatum
HP:0000768Pectus carinatum
HP:0001250Seizure
HP:0001252Hypotonia
HP:0001513Obesity
HP:0002007Frontal bossing
HP:0002650Scoliosis
HP:0002808Kyphosis
HP:0004322Short stature
HP:0007302Bipolar affective disorder
HP:0030680Abnormal cardiovascular system morphology

Эпидемиология (1)

Point prevalence
Unknown
Worldwide

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы