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Juvenile Paget disease

ORPHA:2801Malformation syndromeAutosomal recessiveChildhood

Ассоциированные гены (2)

TNFRSF11B
TNF receptor superfamily member 11b
Disease-causing germline mutation(s) in
OMIM: 602643
TNFRSF11A
TNF receptor superfamily member 11a
Candidate gene tested in
OMIM: 603499

Фенотипы (17)

Очень частый (80–99%)10
HP:0000164Abnormality of the dentition
HP:0000256Macrocephaly
HP:0000889Abnormality of the clavicle
HP:0000939Osteoporosis
HP:0002149Hyperuricemia
HP:0002757Recurrent fractures
HP:0004322Short stature
HP:0004437Cranial hyperostosis
HP:0006487Bowing of the long bones
HP:0100670Rough bone trabeculation
Частый (30–79%)5
HP:0000365Hearing impairment
HP:0000648Optic atrophy
HP:0000768Pectus carinatum
HP:0000822Hypertension
HP:0007703Abnormality of retinal pigmentation
Периодический (5–29%)2
HP:0000995Melanocytic nevus
HP:0001482Subcutaneous nodule

Эпидемиология (2)

Cases/families
Worldwide
Point prevalence
<1 / 1 000 000
Worldwide

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы