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Spectrin-associated autosomal recessive cerebellar ataxia

ORPHA:352403DiseaseAutosomal recessiveInfancy

Ассоциированные гены (1)

SPTBN2
spectrin beta, non-erythrocytic 2
Disease-causing germline mutation(s) (loss of function) in
OMIM: 604985

Фенотипы (20)

Очень частый (80–99%)1
HP:0002073Progressive cerebellar ataxia
Частый (30–79%)11
HP:0000750Delayed speech and language development
HP:0001256Intellectual disability, mild
HP:0001260Dysarthria
HP:0001263Global developmental delay
HP:0001272Cerebellar atrophy
HP:0001310Dysmetria
HP:0001347Hyperreflexia
HP:0001350Slurred speech
HP:0002075Dysdiadochokinesis
HP:0002078Truncal ataxia
HP:0007240Progressive gait ataxia
Периодический (5–29%)8
HP:0000486Strabismus
HP:0000639Nystagmus
HP:0000641Dysmetric saccades
HP:0000651Diplopia
HP:0000666Horizontal nystagmus
HP:0001257Spasticity
HP:0002080Intention tremor
HP:0008003Jerky ocular pursuit movements

Эпидемиология (2)

Cases/families
Worldwide
Point prevalence
<1 / 1 000 000
Worldwide

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы