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FBLN1-related developmental delay-central nervous system anomaly-syndactyly syndrome

ORPHA:404451Malformation syndromeAutosomal recessiveNeonatal

Ассоциированные гены (1)

FBLN1
fibulin 1
Disease-causing germline mutation(s) in
OMIM: 135820

Фенотипы (18)

Частый (30–79%)18
HP:0000028Cryptorchidism
HP:0000608Macular degeneration
HP:0000750Delayed speech and language development
HP:0001159Syndactyly
HP:0001260Dysarthria
HP:0001270Motor delay
HP:0001285Spastic tetraparesis
HP:0001332Dystonia
HP:0002120Cerebral cortical atrophy
HP:0002200Pseudobulbar signs
HP:0002307Drooling
HP:0002342Intellectual disability, moderate
HP:0003396Syringomyelia
HP:0007030Nonprogressive encephalopathy
HP:0008780Congenital bilateral hip dislocation
HP:0011506Choroidal neovascularization
HP:0012469Infantile spasms
HP:0031936Delayed ability to walk

Эпидемиология (2)

Cases/families
Worldwide
Point prevalence
<1 / 1 000 000
Worldwide

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы