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Branchiootic syndrome

ORPHA:52429Malformation syndromeAutosomal dominantNeonatal

Ассоциированные гены (2)

EYA1
EYA transcriptional coactivator and phosphatase 1
Disease-causing germline mutation(s) in
OMIM: 601653
SIX1
SIX homeobox 1
Disease-causing germline mutation(s) in
OMIM: 601205

Фенотипы (16)

Очень частый (80–99%)2
HP:0004467Preauricular pit
HP:0000365Hearing impairment
Частый (30–79%)7
HP:0000356Abnormality of the outer ear
HP:0000359Abnormality of the inner ear
HP:0000405Conductive hearing impairment
HP:0000407Sensorineural hearing impairment
HP:0000413Atresia of the external auditory canal
HP:0008609Morphological abnormality of the middle ear
HP:0009795Branchial fistula
Периодический (5–29%)7
HP:0000324Facial asymmetry
HP:0000347Micrognathia
HP:0000384Preauricular skin tag
HP:0010628Facial palsy
HP:0000175Cleft palate
HP:0000614Abnormal nasolacrimal system morphology
HP:0100267Lip pit

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы