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X-linked recessive ocular albinism

ORPHA:54DiseaseX-linked recessiveInfancy, Neonatal

Ассоциированные гены (2)

AP3D1
adaptor related protein complex 3 subunit delta 1
Candidate gene tested in
OMIM: 607246
GPR143
G protein-coupled receptor 143
Disease-causing germline mutation(s) in
OMIM: 300808

Фенотипы (14)

Очень частый (80–99%)6
HP:0000483Astigmatism
HP:0000613Photophobia
HP:0000615Abnormal pupil morphology
HP:0000639Nystagmus
HP:0001107Ocular albinism
HP:0007730Iris hypopigmentation
Частый (30–79%)4
HP:0000486Strabismus
HP:0001103Abnormal macular morphology
HP:0001480Freckling
HP:0007750Hypoplasia of the fovea
Периодический (5–29%)4
HP:0000505Visual impairment
HP:0000545Myopia
HP:0005592Giant melanosomes in melanocytes
HP:0008069Neoplasm of the skin

Эпидемиология (6)

Prevalence at birth
1-9 / 1 000 000
Europe
Point prevalence
1-9 / 1 000 000
Europe
Prevalence at birth
1-9 / 1 000 000
Denmark
Point prevalence
1-9 / 1 000 000
Denmark
Prevalence at birth
1-9 / 100 000
United States
Point prevalence
1-9 / 100 000
United States

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы