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Severe hereditary thrombophilia due to congenital protein S deficiency

ORPHA:743DiseaseAutosomal recessiveInfancy, Neonatal

Ассоциированные гены (1)

PROS1
protein S
Disease-causing germline mutation(s) in
OMIM: 176880

Фенотипы (14)

Очень частый (80–99%)1
HP:0000979Purpura
Частый (30–79%)6
HP:0000488Retinopathy
HP:0000963Thin skin
HP:0001933Subcutaneous hemorrhage
HP:0002625Deep venous thrombosis
HP:0004418Thrombophlebitis
HP:0008065Aplasia/Hypoplasia of the skin
Периодический (5–29%)7
HP:0001000Abnormality of skin pigmentation
HP:0002204Pulmonary embolism
HP:0004420Arterial thrombosis
HP:0005293Venous insufficiency
HP:0100659Abnormality of the cerebral vasculature
HP:0100758Gangrene
HP:0200042Skin ulcer

Эпидемиология (2)

Point prevalence
Unknown
Worldwide
Prevalence at birth
Unknown
Europe

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы