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Enlarged parietal foramina

ORPHA:60015Malformation syndromeAutosomal dominantAntenatal, Neonatal

Ассоциированные гены (2)

ALX4
ALX homeobox 4
Disease-causing germline mutation(s) (loss of function) in
OMIM: 605420
MSX2
msh homeobox 2
Disease-causing germline mutation(s) (loss of function) in
OMIM: 123101

Фенотипы (20)

Очень частый (80–99%)1
HP:0002697Parietal foramina
Периодический (5–29%)5
HP:0000932Abnormality of the posterior cranial fossa
HP:0002013Vomiting
HP:0002315Headache
HP:0012721Venous malformation
HP:0100809Scalp tenderness
Очень редкий (1–4%)14
HP:0000175Cleft palate
HP:0000894Short clavicles
HP:0001249Intellectual disability
HP:0001250Seizure
HP:0001363Craniosynostosis
HP:0002085Occipital encephalocele
HP:0002475Myelomeningocele
HP:0002762Multiple exostoses
HP:0007385Aplasia cutis congenita of scalp
HP:0008497Congenital craniofacial dysostosis
HP:0011304Broad thumb
HP:0012480Abnormality of cerebral veins
HP:0040197Encephalomalacia
HP:0410030Cleft lip

Эпидемиология (2)

Point prevalence
1-9 / 100 000
Europe
Point prevalence
1-9 / 100 000
Worldwide

Лекарства и терапия

Источник: Open Targets Platform (в реальном времени)

Клинические исследования

Источник: ClinicalTrials.gov (в реальном времени)

Внешние ресурсы