Precursor T-cell acute lymphoblastic leukemia
ORPHA:99861DiseaseNot applicableAdolescent, Adult
Ассоциированные гены23
| Ген | Полное название | Тип связи | Тип гена | OMIM |
|---|---|---|---|---|
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase | Part of a fusion gene in | gene with protein product | 189980 |
| SET | SET nuclear proto-oncogene | Part of a fusion gene in | gene with protein product | 600960 |
| NUP214 | nucleoporin 214 | Part of a fusion gene in | gene with protein product | 114350 |
| ZBTB16 | zinc finger and BTB domain containing 16 | Part of a fusion gene in | gene with protein product | 176797 |
| SALL2 | spalt like transcription factor 2 | Part of a fusion gene in | gene with protein product | 602219 |
| TRA | T-cell receptor alpha locus | Part of a fusion gene in | gene with protein product | — |
| BCR | BCR activator of RhoGEF and GTPase | Part of a fusion gene in | gene with protein product | 151410 |
| CDKN2A | cyclin dependent kinase inhibitor 2A | Disease-causing somatic mutation(s) in | gene with protein product | 600160 |
| TAL1 | TAL bHLH transcription factor 1, erythroid differentiation factor | Part of a fusion gene in | gene with protein product | 187040 |
| FLT3 | fms related receptor tyrosine kinase 3 | Disease-causing somatic mutation(s) in | gene with protein product | 136351 |
| MYC | MYC proto-oncogene, bHLH transcription factor | Part of a fusion gene in | gene with protein product | 190080 |
| STIL | STIL centriolar assembly protein | Part of a fusion gene in | gene with protein product | 181590 |
| MYB | MYB proto-oncogene, transcription factor | Part of a fusion gene in | gene with protein product | 189990 |
| TRB | T-cell receptor beta locus | Part of a fusion gene in | gene with protein product | — |
| TRD | T-cell receptor delta locus | Part of a fusion gene in | gene with protein product | — |
| TRG | T-cell receptor gamma locus | Candidate gene tested in | gene with protein product | — |
| TCL1A | TCL1 family AKT coactivator A | Part of a fusion gene in | gene with protein product | 186960 |
| TLX1 | T cell leukemia homeobox 1 | Part of a fusion gene in | gene with protein product | 186770 |
| TLX3 | T cell leukemia homeobox 3 | Part of a fusion gene in | gene with protein product | 604640 |
| CNOT3 | CCR4-NOT transcription complex subunit 3 | Disease-causing somatic mutation(s) in | gene with protein product | 604910 |
| MLLT10 | MLLT10 histone lysine methyltransferase DOT1L cofactor | Part of a fusion gene in | gene with protein product | 602409 |
| DDX3X | DEAD-box helicase 3 X-linked | Part of a fusion gene in | gene with protein product | 300160 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | Part of a fusion gene in | gene with protein product | 603025 |
Лекарства и терапия
Источник: Open Targets Platform (в реальном времени)
Клинические исследования
Источник: ClinicalTrials.gov (в реальном времени)